n-glucosides: new phase-ii metabolites of two barbiturates

نویسندگان

ma al-sharifi from the department of pharmacology, qazvin university of medical sciences, qazvin, islamic republic of iran.

چکیده

the new phase-ii n-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. the identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). it was found that the butobarbitone n-glucoside comprised 26% of the dose with tl/2= 44h, while the pentobarbitone n-glucoside was 43% with t1/2= 40h.

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N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۶، شماره ۱، صفحات ۶۳-۶۶

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